Project: COLD-CE

COLD-CE: Cold urticaria and other cold-induced reactions – Comprehensive Evaluation

This international, multi-center, prospective and partly retrospective, observational, cross-sectional academic study aims to improve the understanding of cold urticaria and cold-induced anaphylaxis. Optimal evaluation strategies need to be defined. We hope this project will spread globally and to help improve patient care.

Study type: Questionnaire (physician and patient), stimulation testing

We intend to present the study results at an international congress (preferably EADV or EAACI) and to publish them in peer-reviewed scientific journals. To become a coauthor, you need to include at least 10 patients and contribute to the interpretation of study results and manuscript development. Additional co-authorship criteria are: 15 included patients more = another additional co-authorship, 30 included patients more = another additional co-authorship. The sequence of coauthors who contributed equally to data interpretation and manuscript development will be based on the number of patients included.

Project Lead Mojca Bizjak, Dorothea Terhorst-Molawi
Project Advisor Kanokvalai Kulthanan, Marcus Maurer
Steering Committee Mitja Košnik, Kanokvalai Kulthanan, Marcus Maurer, Raisa Meshkova, Simon Francis Thomsen
Study Ended August 2026
Scientific output

Publications

04 Publications
01
Allergy 2022

Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study

Bizjak M, Košnik M, Dinevski D, et al. Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study. Allergy. 2022;77:2185–2199. doi:10.1111/all.15194.

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02
Allergy 2022

Adrenaline autoinjector is underprescribed in typical cold urticaria patients

Bizjak M, Košnik M, Dinevski D, Thomsen SF, et al. Adrenaline autoinjector is underprescribed in typical cold urticaria patients. Allergy. 2022 Jul;77(7):2224–2229. doi:10.1111/all.15274. PMID: 35258111.

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03
JEADV 2026

Mucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights

Bizjak M, Fomina D, Peter J, Giménez-Arnau AM, et al. Mucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights. Journal of the European Academy of Dermatology and Venereology. PMID: 40698997.

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04
JACI: In Practice 2026

Cold urticaria with negative standard cold stimulation testing: Results from the COLD-CE study

Cold urticaria with negative standard cold stimulation testing: Results from the COLD-CE study. The Journal of Allergy and Clinical Immunology: In Practice. 2026.

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