COLD-CE: Cold urticaria and other cold-induced reactions – Comprehensive Evaluation
This international, multi-center, prospective and partly retrospective, observational, cross-sectional academic study aims to improve the understanding of cold urticaria and cold-induced anaphylaxis. Optimal evaluation strategies need to be defined. We hope this project will spread globally and to help improve patient care.
Study type: Questionnaire (physician and patient), stimulation testing
We intend to present the study results at an international congress (preferably EADV or EAACI) and to publish them in peer-reviewed scientific journals. To become a coauthor, you need to include at least 10 patients and contribute to the interpretation of study results and manuscript development. Additional co-authorship criteria are: 15 included patients more = another additional co-authorship, 30 included patients more = another additional co-authorship. The sequence of coauthors who contributed equally to data interpretation and manuscript development will be based on the number of patients included.
Publications
Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study
Bizjak M, Košnik M, Dinevski D, et al. Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study. Allergy. 2022;77:2185–2199. doi:10.1111/all.15194.
View on PubMedAdrenaline autoinjector is underprescribed in typical cold urticaria patients
Bizjak M, Košnik M, Dinevski D, Thomsen SF, et al. Adrenaline autoinjector is underprescribed in typical cold urticaria patients. Allergy. 2022 Jul;77(7):2224–2229. doi:10.1111/all.15274. PMID: 35258111.
View on PubMedMucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights
Bizjak M, Fomina D, Peter J, Giménez-Arnau AM, et al. Mucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights. Journal of the European Academy of Dermatology and Venereology. PMID: 40698997.
View on PubMedCold urticaria with negative standard cold stimulation testing: Results from the COLD-CE study
Cold urticaria with negative standard cold stimulation testing: Results from the COLD-CE study. The Journal of Allergy and Clinical Immunology: In Practice. 2026.
View on PubMed